What are Polynucleotides?

Polynucleotides are naturally occurring molecules derived from purified DNA fragments. In aesthetic and regenerative medicine, they are used to repair, regenerate, and strengthen skin at a cellular level, rather than simply adding volume or altering facial shape.

Croma Polynucleotides work by stimulating fibroblast activity, improving skin elasticity, hydration, and resilience while supporting the skin’s natural repair processes. The result is healthier, stronger, more youthful skin over time — not an instant or artificial change.

This treatment is particularly suited to patients seeking skin longevity, subtle rejuvenation, and long-term improvement in skin quality.

What Does Croma Polynucleotides Treat?

Croma Polynucleotides are ideal for areas where the skin is thin, fragile, or showing early signs of ageing, including:

• Under-eye crepiness and fine lines

• Loss of skin elasticity and firmness

• Dull, dehydrated, or tired-looking skin

• Early skin ageing and environmental damage

• Skin that no longer responds well to traditional treatments

They are suitable for the face, neck, décolletage, and hands, and can be used safely in delicate areas where fillers are not appropriate.

How Do Polynucleotides Work?

Rather than filling or tightening the skin mechanically, polynucleotides act as biological repair signals. Once injected, they:

• Stimulate collagen and elastin production

• Improve microcirculation and tissue quality

• Enhance hydration and skin density

• Support cellular repair and regeneration

This makes them an excellent option for patients who want natural, progressive improvement and value skin health over quick fixes.

What Results Can I Expect?

Results develop gradually as the skin regenerates. Patients typically notice:

• Improved skin texture and hydration

• Increased firmness and elasticity

• Brighter, healthier-looking skin

• Softening of fine lines, particularly under the eyes

The focus is not dramatic change, but skin that looks and behaves younger.

Treatment Plan & Longevity

For optimal results, a course of treatments is recommended:

• Typically 2–3 sessions, spaced 3–4 weeks apart

• Maintenance treatments may be advised depending on skin condition and goals

Polynucleotides work exceptionally well as part of a skin longevity or regenerative programme, alongside other evidence-based treatments.

Is This Treatment Right for Me?

Croma Polynucleotides are suitable for men and women who:

• Prefer subtle, natural results

• Are concerned about skin quality rather than volume

• Want preventative or restorative skin care

• Are experiencing early or advanced skin ageing

A full medical consultation is required to assess suitability and create a personalised treatment plan.

Medical-Led, Evidence-Based Care

All treatments are performed by a medically trained practitioner, following a comprehensive consultation and skin assessment. Your safety, long-term skin health, and realistic outcomes are always the priority.

Book a Consultation

If you are interested in improving your skin quality through regenerative medicine rather than traditional injectables, we invite you to book a consultation to discuss whether Croma Polynucleotides are right for you.